BDS, MSc, PhD, M Endo RCS (Eng), M Endo (RCSEd), Specialist list in Endodontics, FHEA
Sadia is a Clinical Lecturer/Honorary Consultant in Endodontics at King’s College London, Guy’s and St Thomas’ NHS Foundation Trust. She is a member of the Royal College of Surgeons of England and Edinburgh.
At King’s, she distributes her time between providing service to the GSTT and leading her research group. Apart from training the King’s Endodontics postgraduates, she is the Endodontics Clinical Lead for King’s Dental undergraduates.
With regards to research, her core area of interest is Endodontics Microbiology, its host-pathogen Interactions and Systemic Impact. She is a Principal Investigator in the ‘Centre of Host Microbiome Interactions’ at King’s College London. Since completing her PhD in Endodontics (Microbiology) from King’s in 2011, she has established a research programme centred on the characterization and control of “Endodontic Biofilms”. She has co-authored multiple publications in high impact scientific journals, written a book chapter, given several talks and chaired sessions at various international scientific conferences, and peer review articles for scientific journals. She has supervised research projects for over 20 MClinDent and PhD students. She pioneered the development of a nutrient-stressed multi-species in vitro endodontic biofilm model, which has been widely used at King’s in various projects. With her extensive experience in culture and gene sequencing techniques, she has profiled the microbiota of endodontic biofilms and made a significant breakthrough in confirming the nosocomial nature of endodontic infections, thus emphasising the need for implementation of enhanced cross infection control protocol. She has expanded her research to investigate the systemic interactions of endodontic microbiome with host immune response that can pose cardiovascular disease risks. She collaborates across various disciplines within KCL and with other leading institutes in the UK, Europe and Asia as well as with industry. At King’s utilising state-of-the-art facilities, expertise and support, she is leading a dynamic research team to pursue the novel innovative high impact projects.
Host-Endodontic Microbiome Interactions and the risk of Cardiovascular Disease.
Apical periodontitis (AP) can contribute to persistent low-grade systemic inflammation which can have adverse impact on general health and quality of life of patient. Studies have attempted to associate AP with systemic conditions such as diabetes and cardiovascular diseases (CVD), however lack of adequate high-quality evidence implies a weak association between CVDs and AP.
The aim of the lecture is to discuss based on the findings of our longitudinal study on Host-Endodontic Microbiome interactions utilising next generation sequencing and biomarker profiling, if AP pose actual risk to CVD development or not.